Rabbit CCM2 Polyclonal Antibody | anti-CCM2 antibody
CCM2
Gene Names
CCM2; OSM; C7orf22; PP10187
Reactivity
HumanPredicted: Rat, Mouse
Applications
ELISA, Western Blot
Purity
Purified By Protein A/G Column
Synonyms
CCM2; Polyclonal Antibody; anti-CCM2 antibody
Host
Rabbit
Reactivity
Human
Predicted: Rat, Mouse
Predicted: Rat, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified By Protein A/G Column
Form/Format
Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
Sequence Length
1828
Applicable Applications for anti-CCM2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: 1:10000-80000
WB: 1:200-1000
WB: 1:200-1000
Immunogen
Recombinant fragment corresponding to 215-425aa of human CCM2.
Cellular Localization
Cytoplasm
Related Product Information for anti-CCM2 antibody
Homo sapiens CCM2 scaffolding protein (CCM2), mRNA.
References
Craig HD, Gunel M, Cepeda O, et al. Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27. Hum Mol Genet. 7 (12):1851-1858 (1998)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
49KD
NCBI Official Full Name
Homo sapiens cerebral cavernous malformation 2, mRNA
NCBI Official Synonym Full Names
CCM2 scaffold protein
NCBI Official Symbol
CCM2
NCBI Official Synonym Symbols
OSM; C7orf22; PP10187
NCBI Protein Information
cerebral cavernous malformations 2 protein
Protein Family
NCBI Description
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Research Articles on CCM2
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Product Notes
The CCM2 (Catalog #AAA8562509) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCM2 reacts with Human Predicted: Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCM2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:10000-80000 WB: 1:200-1000. Researchers should empirically determine the suitability of the CCM2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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