Rabbit anti-Human CACNA1A Polyclonal Antibody | anti-CACNA1A antibody
CACNA1A (Center) Rabbit pAb
NCBI and Uniprot Product Information
Uniprot Description
CACNA1A: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). Defects in CACNA1A are the cause of spinocerebellar ataxia type 6 (SCA6). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder. Defects in CACNA1A are the cause of familial hemiplegic migraine type 1 (FHM1); also known as migraine familial hemiplegic 1 (MHP1). FHM1, a rare autosomal dominant subtype of migraine with aura, is associated with ictal hemiparesis and, in some families, progressive cerebellar atrophy. Defects in CACNA1A are the cause of episodic ataxia type 2 (EA2); also known as acetazolamide-responsive hereditary paroxysmal cerebellar ataxia (APCA). EA2 is an autosomal dominant disorder characterized by acetozolamide- responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: cell projection; cell soma; dendrite; cytoplasm; plasma membrane; integral to membrane; voltage-gated calcium channel complex; nucleus
Molecular Function: voltage-gated calcium channel activity; protein binding; syntaxin binding; metal ion binding; high voltage-gated calcium channel activity
Biological Process: cell death; vestibular nucleus development; musculoskeletal movement, spinal reflex action; gamma-aminobutyric acid secretion; regulation of axonogenesis; adult walking behavior; receptor clustering; cellular chloride ion homeostasis; synaptic transmission; behavioral response to pain; elevation of cytosolic calcium ion concentration; synaptogenesis; neurotransmitter metabolic process; negative regulation of neuron apoptosis; neuromuscular process controlling balance; cell growth; cerebellum maturation; synaptic transmission, glutamatergic; rhythmic synaptic transmission; regulation of acetylcholine secretion; dendrite morphogenesis; calcium ion-dependent exocytosis of neurotransmitter; glucose metabolic process; transmission of nerve impulse; spinal cord motor neuron differentiation; regulation of calcium ion-dependent exocytosis; cerebellar molecular layer development; calcium ion-dependent exocytosis; membrane depolarization; sulfur amino acid metabolic process; cerebellar Purkinje cell differentiation; energy reserve metabolic process; neuromuscular synaptic transmission; hormone metabolic process; regulation of insulin secretion; negative regulation of hormone biosynthetic process; gamma-aminobutyric acid signaling pathway
Disease: Spinocerebellar Ataxia 6; Migraine, Familial Hemiplegic, 1; Episodic Ataxia, Type 2
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Product Notes
The CACNA1A cacna1a (Catalog #AAA8557582) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CACNA1A (Center) Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CACNA1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2000. Researchers should empirically determine the suitability of the CACNA1A cacna1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CACNA1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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