Rabbit anti-Human SEC11A Polyclonal Antibody | anti-SEC11A antibody

SEC11A (Center) Rabbit pAb

Cat. Num. AAA8557027

• Gene Names: SEC11A; SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: SEC11A; Polyclonal Antibody; SEC11A (Center) Rabbit pAb; Signal peptidase complex catalytic subunit SEC11A; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SPase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18; SEC11L1; SPCS4A; anti-SEC11A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Purity/Purification: Affinity Purified
• Form/Format: Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 179

• Applicable Applications for anti-SEC11A antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Immunogen: This SC11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the central region of human SC11A.
• Cellular Localization: Endoplasmic Reticulum, Membrane, Microsome

NCBI and Uniprot Product Information

• NCBI GI #: 7657609
• NCBI GeneID: 23478
• NCBI Accession #: NP_055115.1
• NCBI GenBank Nucleotide #: NP_055115.1
• UniProt Accession #: P67812
• NCBI Official Full Name: signal peptidase complex catalytic subunit SEC11A isoform 2
• NCBI Official Synonym Full Names: SEC11 homolog A, signal peptidase complex subunit
• NCBI Official Symbol: SEC11A
• NCBI Official Synonym Symbols: SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
• NCBI Protein Information: signal peptidase complex catalytic subunit SEC11A
• UniProt Protein Name: Signal peptidase complex catalytic subunit SEC11A
• Protein Family: Signal peptidase complex
• UniProt Gene Name: SEC11A
• UniProt Synonym Gene Names: SEC11L1; SPC18; SPCS4A; SPase 18 kDa subunit
• UniProt Entry Name: SC11A_HUMAN

NCBI Description

This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

Uniprot Description

SEC11A: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the peptidase S26B family.

Protein type: EC 3.4.21.89; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: serine-type peptidase activity

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; signal peptide processing; gene expression; proteolysis; regulation of insulin secretion