NCBI Description
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: Golgi apparatus; clathrin-coated vesicle; membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; brush border
Molecular Function: protein binding; G-protein alpha-subunit binding; GTPase activator activity
Biological Process: G-protein coupled receptor protein signaling pathway; small GTPase mediated signal transduction; autophagy; positive regulation of GTPase activity
Product Notes
The RGS19 rgs19 (Catalog #
AAA8554052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RGS19 (Phospho-Ser24) Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RGS19 can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB). DB: 1:500. Researchers should empirically determine the suitability of the RGS19 rgs19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"RGS19, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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