Rabbit anti-Human LIN7C Polyclonal Antibody | anti-LIN7C antibody

LIN7C (C-Term) Rabbit pAb

Cat. Num. AAA8551827

• Gene Names: LIN7C; MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified
• Synonyms: LIN7C; Polyclonal Antibody; LIN7C (C-Term) Rabbit pAb; Protein lin-7 homolog C; Lin-7C; Mammalian lin-seven protein 3; MALS-3; Vertebrate lin-7 homolog 3; Veli-3; MALS3; VELI3; anti-LIN7C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Clone Number: RB32322
• Purity/Purification: Affinity Purified
• Form/Format: Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 197

• Applicable Applications for anti-LIN7C antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1000; IHC: 1:10-50
• Immunogen: This LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human LIN7C.
• Cellular Localization: Cell Junction, Cell Membrane, Membrane, Postsynaptic Cell Membrane, Synapse, Synaptosome, Tight Junction

NCBI and Uniprot Product Information

• NCBI GI #: 8922944
• NCBI GeneID: 55327
• NCBI Accession #: NP_060832.1
• NCBI GenBank Nucleotide #: NP_060832.1
• UniProt Accession #: Q9NUP9
• NCBI Official Full Name: protein lin-7 homolog C
• NCBI Official Synonym Full Names: lin-7 homolog C, crumbs cell polarity complex component
• NCBI Official Symbol: LIN7C
• NCBI Official Synonym Symbols: MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• NCBI Protein Information: protein lin-7 homolog C
• UniProt Protein Name: Protein lin-7 homolog C
• Protein Family: Protein
• UniProt Gene Name: LIN7C
• UniProt Synonym Gene Names: MALS3; VELI3; Lin-7C; MALS-3; Veli-3
• UniProt Entry Name: LIN7C_HUMAN

Uniprot Description

LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction

Molecular Function: protein domain specific binding; cytoskeletal protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; morphogenesis of an epithelial sheet; maintenance of epithelial cell polarity