Mouse CD44v6 Monoclonal Antibody | anti-CD44v6 antibody

CD44v6 Antibody

Cat. Num. AAA854086

• Gene Names: CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
• Synonyms: CD44v6; Monoclonal Antibody; CD44v6 Antibody; anti-CD44v6 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: Anti-CD44v6 recognizes recombinant protein CD44v6
• Form/Format: Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
• Sequence Length: 742

• Immunogen: Recombinant protein corresponding to full length CD44v6. SWISS-PROT KEY CD44v6 [P16070]
• Preparation and Storage: The antibody may be stored at-20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

Immunohistochemistry

(IHC (1:1000, 400X) analysis of recombinant protein CD44V6 with Anti-CD44.)

Related Product Information for anti-CD44v6 antibody

Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein CD44v6 as immunogen.

Product Categories/Family for anti-CD44v6 antibody

Plant antibody

NCBI and Uniprot Product Information

• NCBI GI #: 48255935
• NCBI GeneID: 960
• NCBI Accession #: NP_000601.3
• NCBI GenBank Nucleotide #: NM_000610.3
• UniProt Accession #: P16070; O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; A5YRN9; B6EAT9; D3DR12; D3DR13
• Molecular Weight: 15,635 Da
• NCBI Official Full Name: CD44 antigen isoform 1
• NCBI Official Synonym Full Names: CD44 molecule (Indian blood group)
• NCBI Official Symbol: CD44
• NCBI Official Synonym Symbols: IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
• NCBI Protein Information: CD44 antigen
• UniProt Protein Name: CD44 antigen
• UniProt Gene Name: CD44
• UniProt Synonym Gene Names: LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I

NCBI Description

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function ().