anti-Human, Mouse TMPRSS3 Antibody | anti-TMPRSS3 antibody

TMPRSS3 Antibody

Cat. Num. AAA852884

• Gene Names: TMPRSS3; DFNB8; DFNB10; ECHOS1; TADG12
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TMPRSS3; TMPRSS3 Antibody; Transmembrane protease; serine 3; EC 3.4.21.-; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein; ECHOS1; TADG12; anti-TMPRSS3 antibody

• Reactivity: Human, Mouse
• Specificity: TMPRSS3 antibody detects endogenous levels of total TMPRSS3 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 453

• Applicable Applications for anti-TMPRSS3 antibody: Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IF: 1:100~1:500; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human TMPRSS3.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

Western Blot (WB)

(Peptide-+ Western blot analysis of extracts from HUVEC cells, using TMPRSS3 antibody. Immunofluorescence analysis of HeLa cells, using TMPRSS3 antibody.)

Product Categories/Family for anti-TMPRSS3 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Underwood L.J., Biochim. Biophys. Acta 1502:337-350(2000). Scott H.S., Nat. Genet. 27:59-63(2001). Clark H.F., Genome Res. 13:2265-2270(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 373251166
• NCBI GeneID: 64699
• NCBI Accession #: NP_001243246.1
• NCBI GenBank Nucleotide #: NM_001256317.1
• UniProt Accession #: P57727; Q5USC7; Q6ZMC3; D3DSJ6
• Molecular Weight: 58,324 Da
• NCBI Official Full Name: transmembrane protease serine 3 isoform 4
• NCBI Official Synonym Full Names: transmembrane serine protease 3
• NCBI Official Symbol: TMPRSS3
• NCBI Official Synonym Symbols: DFNB8; DFNB10; ECHOS1; TADG12
• NCBI Protein Information: transmembrane protease serine 3
• UniProt Protein Name: Transmembrane protease serine 3
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS3
• UniProt Synonym Gene Names: ECHOS1; TADG12

NCBI Description

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Uniprot Description

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (). Activates ENaC (in vitro).