anti-Human CD1E Antibody | anti-CD1E antibody

CD1E Antibody

Cat. Num. AAA852704

• Gene Names: CD1E; R2; CD1A
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CD1E; CD1E Antibody; T-cell surface glycoprotein CD1e; CD1e antigen; R2G1; anti-CD1E antibody

• Reactivity: Human
• Specificity: CD1E antibody detects endogenous levels of total CD1E protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 376

• Applicable Applications for anti-CD1E antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CD1E.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data #2

(Western blot analysis of extracts from HuvEc cells and HepG2 cells, using CD1E antibody.)

Product Categories/Family for anti-CD1E antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Calabi F., Eur. J. Immunol. 19:285-292(1989). Angenieux C., J. Biol. Chem. 275:37757-37764(2000). Gregory S.G., Nature 441:315-321(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 110618230
• NCBI GeneID: 913
• NCBI Accession #: NP_001036048.1
• NCBI GenBank Nucleotide #: NM_001042583.2
• UniProt Accession #: P15812; Q5TDJ9; Q5TDK3; Q5TDK4; Q5TDK5; Q5TDK6; Q5TDK8; Q5TDL1; Q712E4; Q712E5; B4DZV3; E7EP01
• Molecular Weight: 32,303 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD1e, membrane-associated isoform b
• NCBI Official Synonym Full Names: CD1e molecule
• NCBI Official Symbol: CD1E
• NCBI Official Synonym Symbols: R2; CD1A
• NCBI Protein Information: T-cell surface glycoprotein CD1e, membrane-associated
• UniProt Protein Name: T-cell surface glycoprotein CD1e, membrane-associated
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD1E
• UniProt Synonym Gene Names: hCD1e; sCD1e

NCBI Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Description

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.