anti-Human ASXL2 Antibody | anti-ASXL2 antibody

ASXL2 Antibody

Cat. Num. AAA8526856

• Gene Names: ASXL2; ASXH2; SHAPNS
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Protein G-Sepharose affinity purified.
• Synonyms: ASXL2; ASXL2 Antibody; Mouse monoclonal IgG to ASXL2; anti-ASXL2 antibody

• Reactivity: Human
• Purity/Purification: Protein G-Sepharose affinity purified.
• Form/Format: Liquid
• Sequence Length: 1435

• Applicable Applications for anti-ASXL2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:5000-1:20000; WB: 1:100-1:2000
• Immunogen: Recombinant fragment of human ASXL2 (N-terminus).
• Preservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
• Preparation and Storage: Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

(ASXL2 (N-terminus) antibody at 1/2000 dilution + recombinant ASXL2protein with a His tag. Predicted band size: 40KDa. Observed band size: 40KDa.)

Related Product Information for anti-ASXL2 antibody

ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing.

NCBI and Uniprot Product Information

• NCBI GI #: 153792780
• NCBI GeneID: 55252
• NCBI Accession #: NP_060733.4
• NCBI GenBank Nucleotide #: NM_018263
• UniProt Accession #: Q76L83; Q53TC9; Q5H9U4; Q76L81; Q86XM1; Q9C0H8; Q9NV67
• Molecular Weight: 98,359 Da
• NCBI Official Full Name: putative Polycomb group protein ASXL2
• NCBI Official Synonym Full Names: ASXL transcriptional regulator 2
• NCBI Official Symbol: ASXL2
• NCBI Official Synonym Symbols: ASXH2; SHAPNS
• NCBI Protein Information: putative Polycomb group protein ASXL2
• UniProt Protein Name: Putative Polycomb group protein ASXL2
• Protein Family: Putative Polycomb group protein
• UniProt Gene Name: ASXL2
• UniProt Synonym Gene Names: ASXH2; KIAA1685

NCBI Description

This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017]

Uniprot Description

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.