Immunohistochemsitry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human-uterus tissue.1. MICU1 Monoclonal Antibody(Mix) was diluted at 1:200 (4 degree C,overnight).2. Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree C, 20 min).3. Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.)
Rabbit MICU1 Monoclonal Antibody | anti-MICU1 antibody
MICU1 Monoclonal Antibody
ELISA: 1/5000.
Not yet tested in other applications.
Subcellular Location: nucleoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, membrane, integral component of membrane.
Expression: Kidney, Platelet, Skin.
Immunohistochemsitry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human-uterus tissue.1. MICU1 Monoclonal Antibody(Mix) was diluted at 1:200 (4 degree C,overnight).2. Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree C, 20 min).3. Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.)
Immunohistochemsitry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human-uterus tissue.1. MICU1 Monoclonal Antibody(Mix) was diluted at 1:200 (4 degree C,overnight).2. Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree C, 20 min).3. Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.)
Western Blot (WB)
( Analysis of:1) MCF72) Mouse Brain Tissue3) Rat Brain Tissue using MICU1 Monoclonal Antibody.)
Western Blot (WB)
( Analysis of:1) MCF72) Mouse Brain Tissue3) Rat Brain Tissue using MICU1 Monoclonal Antibody.)
NCBI and Uniprot Product Information
Observed Band(KD): 50
NCBI Description
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Uniprot Description
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).
Research Articles on MICU1
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Product Notes
The MICU1 micu1 (Catalog #AAA8519610) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MICU1 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MICU1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. Researchers should empirically determine the suitability of the MICU1 micu1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MICU1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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