DYN1 Antibody | anti-DYN1 antibody

Phospho-DYN1 (Ser778) Antibody

Cat. Num. AAA8510578

• Gene Names: DNM1; DNM; EIEE31
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: DYN1; Phospho-DYN1 (Ser778) Antibody; B-dynamin; D100; DNM; DNM1; Dynamin BREDNM19; Dynamin; brain; dynamin-1; EC 3.6.5.5; anti-DYN1 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: Phospho-DYN1(Ser778) Antibody detects endogenous levels of DYN1 only when phosphorylated at Sersine 778
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 851

• Applicable Applications for anti-DYN1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human DYN1 around the phosphorylation site of Sersine 778
• Preparation and Storage: Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis on mouse brain cell lysate using Phospho-DYN1 (Ser778) Antibody)

Related Product Information for anti-DYN1 antibody

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. This gene is located on chromosome 9. More than sixty highly conserved copies of the 3' region of this gene are found on other chromosomes, particularly chromosomes Y and 15. These copies are referred to as DNM1DN duplicons. Multiple splice variants exist for this gene but only two alternatively spliced transcripts encoding distinct isoforms have been described completely.

NCBI and Uniprot Product Information

• NCBI GI #: 56549117
• NCBI GeneID: 1759
• NCBI Accession #: NP_001005336.1
• NCBI GenBank Nucleotide #: NM_001005336.2
• UniProt Accession #: Q05193; Q5SYX0; Q5SYX2; Q6P3T6; Q86VD2; A6NLM6
• Molecular Weight: 100kDa
• NCBI Official Full Name: dynamin-1 isoform 2
• NCBI Official Synonym Full Names: dynamin 1
• NCBI Official Symbol: DNM1
• NCBI Official Synonym Symbols: DNM; EIEE31
• NCBI Protein Information: dynamin-1
• UniProt Protein Name: Dynamin-1
• UniProt Gene Name: DNM1
• UniProt Synonym Gene Names: DNM

NCBI Description

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.