anti-Human, Mouse TIRAP Antibody | anti-TIRAP antibody

TIRAP Antibody

Cat. Num. AAA8510363

• Gene Names: TIRAP; Mal; wyatt; BACTS1; MyD88-2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TIRAP; TIRAP Antibody; Adaptor protein Wyatt; MAL; MyD88 adapter-like protein; TIR domain-containing adapter protein; Toll-interleukin 1 receptor domain-containing adapter protein; anti-TIRAP antibody

• Reactivity: Human, Mouse
• Specificity: TIRAP antibody detects endogenous levels of total TIRAP protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 221

• Applicable Applications for anti-TIRAP antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from Internal of human TIRAP.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using TIRAP antibody.)

References

Fitzgerald K.A., Nature 413:78-83(2001). Horng T., Nat. Immunol. 2:835-841(2001). The MGC Project Team; Genome Res. 14:2121-2127(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 89111122
• NCBI GeneID: 114609
• NCBI Accession #: NP_001034750.1
• NCBI GenBank Nucleotide #: NM_001039661.1
• UniProt Accession #: P58753; Q56UH9; Q56UI0; Q8N5E5; B3KW65
• Molecular Weight: 27,948 Da
• NCBI Official Full Name: toll/interleukin-1 receptor domain-containing adapter protein isoform a
• NCBI Official Synonym Full Names: TIR domain containing adaptor protein
• NCBI Official Symbol: TIRAP
• NCBI Official Synonym Symbols: Mal; wyatt; BACTS1; MyD88-2
• NCBI Protein Information: toll/interleukin-1 receptor domain-containing adapter protein
• UniProt Protein Name: Toll/interleukin-1 receptor domain-containing adapter protein
• Protein Family: Toll/interleukin-1 receptor domain-containing adapter protein
• UniProt Gene Name: TIRAP
• UniProt Synonym Gene Names: MAL; TIR domain-containing adapter protein; MyD88-2

NCBI Description

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Description

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.