anti-Human CDK5RAP2 Antibody | anti-CDK5RAP2 antibody

CDK5RAP2 Antibody

Cat. Num. AAA8509817

• Gene Names: CDK5RAP2; C48; MCPH3; Cep215
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CDK5RAP2; CDK5RAP2 Antibody; C5P2; CDK5 activator-binding protein C48; CK5P2; KIAA1633; CDK5 regulatory subunit associated protein 2; anti-CDK5RAP2 antibody

• Reactivity: Human
• Specificity: CDK5RAP2 antibody detects endogenous levels of total CDK5RAP2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 1814

• Applicable Applications for anti-CDK5RAP2 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human CDK5RAP2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CDK5RAP2 antibody.)

References

Nagase T., DNA Res. 7:273-281(2000). Humphray S.J., Nature 429:369-374(2004). Ota T., Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 58535453
• NCBI GeneID: 55755
• NCBI Accession #: NP_001011649.1
• NCBI GenBank Nucleotide #: NM_001011649.2
• UniProt Accession #: Q96SN8; Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9
• Molecular Weight: 206,323 Da
• NCBI Official Full Name: CDK5 regulatory subunit-associated protein 2 isoform b
• NCBI Official Synonym Full Names: CDK5 regulatory subunit associated protein 2
• NCBI Official Symbol: CDK5RAP2
• NCBI Official Synonym Symbols: C48; MCPH3; Cep215
• NCBI Protein Information: CDK5 regulatory subunit-associated protein 2
• UniProt Protein Name: CDK5 regulatory subunit-associated protein 2
• Protein Family: CDK5 regulatory subunit-associated protein
• UniProt Gene Name: CDK5RAP2
• UniProt Synonym Gene Names: CEP215; KIAA1633

NCBI Description

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis ().