Testing Data
(Western blot analysis of extracts of mouse heartcell lines, using BSG antibody.)
Rabbit anti-Human BSG Antibody | anti-BSG antibody
BSG Antibody
Gene Names
BSG; OK; 5F7; TCSF; CD147; EMPRIN; EMMPRIN
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purification
Synonyms
BSG; BSG Antibody; 5F7; CD147; EMMPRIN; M6; OK; TCSF; anti-BSG antibody
Host
Rabbit
Reactivity
Human
Isotype
IgG
Purity/Purification
Affinity purification
Sequence Length
269
Applicable Applications for anti-BSG antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Recombinant protein of human BSG
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Testing Data
(Western blot analysis of extracts of mouse heartcell lines, using BSG antibody.)
Testing Data
(Western blot analysis of extracts of mouse heartcell lines, using BSG antibody.)
Related Product Information for anti-BSG antibody
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5, 6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition (7). Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells (8), and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes (9).
Product Categories/Family for anti-BSG antibody
References
1. Biswas, C. et al. (1995) Cancer Res 55, 434-9. 2. Liao, C.G. et al. (2011) Mol Cell Biol 31, 2591-604. 3. Sweeny, L. et al. (2012) Exp Cell Res 318, 1788-98. 4. Lescaille, G. et al. (2012) BMC Cancer 12, 115. 5. Piao, S. et al. (2012) J Cancer Res ClinOncol 138, 627-35. 6. Bi, X.C. et al. (2011) Clin Invest Med 34, E358. 7. Wu, J. et al. (2011) Oncogene 30, 4410-27. 8. Solstad, T. et al. (2011) Blood 118, 5141-51. 9. Crosnier, C. et al. (2011) Nature 480, 534-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42kDa
NCBI Official Full Name
basigin isoform 2
NCBI Official Synonym Full Names
basigin (Ok blood group)
NCBI Official Symbol
BSG
NCBI Official Synonym Symbols
OK; 5F7; TCSF; CD147; EMPRIN; EMMPRIN
NCBI Protein Information
basigin
UniProt Protein Name
Basigin
Protein Family
UniProt Gene Name
BSG
UniProt Synonym Gene Names
EMMPRIN; TCSF
NCBI Description
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Research Articles on BSG
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Product Notes
The BSG bsg (Catalog #AAA8504979) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BSG Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BSG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the BSG bsg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BSG, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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