Testing Data
Rabbit Apotransferrin Polyclonal Antibody | anti-TFRC antibody
Apotransferrin Antibody
30 ug (0.5 mg/ml) of antibody in PBS pH 7.2; 0.01 % BSA; 0.03 % ProClin; and 50 % glycerol.
The antibody solution should be gently mixed before use.
Testing Data
Testing Data
Apotransferrin is the ion-free form of Transferrin. Like transferrin; apotransferrin has a physiological role in the transportation and distribution of iron among the body organs. It is also an important transport factor used in defined culture media.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Uniprot Description
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: basolateral plasma membrane; cell surface; clathrin coated vesicle membrane; coated pit; cytoplasmic vesicle; endosome; endosome membrane; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; RNA binding; transferrin receptor activity; transferrin transmembrane transporter activity
Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport
Disease: Immunodeficiency 46
Research Articles on TFRC
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Product Notes
The TFRC tfrc (Catalog #AAA845526) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Apotransferrin Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Apotransferrin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1-4 ug. Researchers should empirically determine the suitability of the TFRC tfrc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Apotransferrin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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