SDS-PAGE
CSF1R/CD115/CD6 Active Protein | CSF1R active protein
Human CellExp CSF1R / CD115 / CD6, human recombinant
After reconstitution, aliquot and store at -20°C or -70°C for up to 3 months. Avoid repeated freezing and thawing cycles. No activity loss was observed after storage in lyophilized state for 1 year (4°C) and after reconstitution under sterile conditions for 3 months (-70°C).
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
The predicted N-terminus is Ile 20. DTT-reduced protein migrates as 80-95 kDa polypeptide in SDS-PAGE.
NCBI Description
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Description
CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.
Protein type: Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; TK group; PDGFR family
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding
Biological Process: regulation of bone resorption; macrophage differentiation; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; monocyte differentiation; protein amino acid autophosphorylation; multicellular organismal development; cytokine and chemokine mediated signaling pathway; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; inflammatory response; intercellular junction maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Research Articles on CSF1R
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Product Notes
The CSF1R csf1r (Catalog #AAA844688) is an Active Protein produced from HEK 293 cells (lle 20 - Glu 512) and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CSF1R/CD115/CD6, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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