Poly(I:C) Biochemical

Poly(I:C)

Cat. Num. AAA8400433

• Purity: >95%
• Synonyms: Poly(I:C); [(2R; 3S; 4R; 5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3; 4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate--[(2R; 5R)-3; 4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate; Polyinosinic acid-polycytidylic acid; Poly I:poly C; Polyinosinic acid; homopolymer; complex with polycytidylic acid; homopolymer (1:1); Poly(I:C) biochemical

• Specificity: A double-stranded homopolymer and Toll-like receptor 3 (TLR3) agonist
• Purity/Purification: >95%
• Form/Format: White to off-white powder

• Solubilities: To prevent denaturation; this product should be reconstituted in solutions with physiological salt concentrations.ultrasonication or gentle warming can be carried out for improving solubility. ~3mg/ml in Water
• Molecular Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x
• InChi: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18; 19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16; 17)18/h2-4; 6-7; 10; 15-16H; 1H2; (H; 11; 12; 17)(H2; 18; 19; 20);1-2; 4; 6-8; 13-14H; 3H2; (H2; 10; 11; 15)(H2; 16; 17; 18)/t4-; 6-; 7-; 10-;4-; 6-; 7-; 8-/m11/s1
• InChi Key: ACEVNMQDUCOKHT-ZLOOHWKQSA-N
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O
• CAS Number: 24939-03-5
• MDL Number: MFCD00131957
• PubChem CID: 135618150
• Preparation and Storage: Store at -20°C.

Structure

Related Product Information for Poly(I:C) biochemical

Poly(I:C) is a double-stranded homopolymer of polyinosinic acid and polycytidylic acid. Transfection of Poly(I:C) (1ug/ml) into NIT 1 cells has been used as a model of intracellular double-stranded RNA-induced beta-cell apoptosis. Poly(I:C) induced apoptosis in 45% of the cells, 18h after transfection. Maturation mixtures containing various cytokines, IFN-gamma and TLR3 agonist poly(I:C) in combination with TLR7/8 agonists R848 or CL075 yield 3-d mature dendritic cells that secrete high levels of IL-12(p70) and show strong chemotaxis to CCR7 ligands. Epigenetic modulation of cardiac progenitor cells with Poly(I:C) accelerates maturation of cardiomyocytes.

Product Categories/Family for Poly(I:C) biochemical

Web Categories; Biochemicals; Biochemicals (A-Z); Signaling Pathways; Toll -Like Receptor (TLR) Signaling; TLR Agonists; Activators-Inducers; Agonists; Toll-Like Receptor (TLR) Agonists

References

https://pubchem.ncbi.nlm.nih.gov/compound/135618150