Rabbit anti-Human ZAK Polyclonal Antibody | anti-ZAK antibody

Anti-ZAK Antibody

Cat. Num. AAA8303983

• Gene Names: MAP3K20; pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by immunogen affinity chromatography.
• Synonyms: ZAK; Polyclonal Antibody; Anti-ZAK Antibody; MLTK; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper-and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif-and leucine zipper-containing kinase AZK; anti-ZAK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of ZAK protein.
• Purity/Purification: Purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
• Sequence Length: 800

• Applicable Applications for anti-ZAK antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ZAK.
• Preparation and Storage: Upon delivery aliquot and store at-20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of ZAK expression in HEK293T (A), HCT116 (B) whole cell lysates.)

Related Product Information for anti-ZAK antibody

Rabbit polyclonal antibody to ZAK

NCBI and Uniprot Product Information

• NCBI GI #: 82880648
• NCBI GeneID: 51776
• NCBI Accession #: NP_057737.2
• NCBI GenBank Nucleotide #: NM_016653.2
• UniProt Accession #: Q9NYL2; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; B3KPG2
• Molecular Weight: 51,582 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 20 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 20
• NCBI Official Symbol: MAP3K20
• NCBI Official Synonym Symbols: pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 20
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 20
• Protein Family: Mitogen-activated protein kinase kinase kinase
• UniProt Gene Name: MAP3K20
• UniProt Synonym Gene Names: HCCS-4; MLK-related kinase; MRK

NCBI Description

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).