AIP sirna

AIP siRNA (Mouse)

Cat. Num. AAA829321

• Gene Names: Aip; Ara9; Xap2; Fkbp16; AA408703; AW476050; D19Bwg1412e
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: AIP; AIP siRNA (Mouse); AH receptor-interacting protein; Aryl-hydrocarbon receptor-interacting protein; AIP sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: AIP siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 330

• Applicable Applications for AIP sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse AIP gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for AIP sirna

siRNA to inhibit AIP expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 443497959
• NCBI GeneID: 11632
• NCBI Accession #: NP_001263213.1
• NCBI GenBank Nucleotide #: NM_001276284.1
• UniProt Accession #: O08915; Q3UJM2
• Molecular Weight: 37,605 Da
• NCBI Official Full Name: AH receptor-interacting protein
• NCBI Official Synonym Full Names: aryl-hydrocarbon receptor-interacting protein
• NCBI Official Symbol: Aip
• NCBI Official Synonym Symbols: Ara9; Xap2; Fkbp16; AA408703; AW476050; D19Bwg1412e
• NCBI Protein Information: AH receptor-interacting protein
• UniProt Protein Name: AH receptor-interacting protein
• Protein Family: AH receptor-interacting protein
• UniProt Gene Name: Aip
• UniProt Synonym Gene Names: AIP
• UniProt Entry Name: AIP_MOUSE

NCBI Description

This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; aryl hydrocarbon receptor binding; unfolded protein binding; transcription cofactor activity

Biological Process: protein maturation via protein folding; protein folding; xenobiotic metabolic process; protein targeting to mitochondrion; negative regulation of cyclic-nucleotide phosphodiesterase activity