Rabbit FDPS Polyclonal Antibody | anti-FDPS antibody

Anti-FDPS Antibody

Cat. Num. AAA8245534

• Gene Names: FDPS; FPS; FPPS; POROK9
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: FDPS; Polyclonal Antibody; Anti-FDPS Antibody; FPS; KIAA1293; Farnesyl pyrophosphate synthase; FPP synthase; (2E; 6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; anti-FDPS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of FDPS protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 353

• Applicable Applications for anti-FDPS antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1/500 - 1/2000; IHC: 1/50 - 1/200
• Immunogen: Recombinant full length protein of human FDPS
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of FDPS expression in HepG2 (A), Hela (B), MCF7 (C), mouse liver (D) whole cell lysates.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of FDPS staining in mouse kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)

Related Product Information for anti-FDPS antibody

Rabbit polyclonal antibody to FDPS

NCBI and Uniprot Product Information

• NCBI GI #: 209571582
• NCBI GeneID: 2224
• NCBI Accession #: NP_001129293.1
• NCBI GenBank Nucleotide #: NM_001135821.1
• UniProt Accession #: P14324; Q96G29; D3DV91; E9PCI9
• Molecular Weight: 40,532 Da
• NCBI Official Full Name: farnesyl pyrophosphate synthase isoform a
• NCBI Official Synonym Full Names: farnesyl diphosphate synthase
• NCBI Official Symbol: FDPS
• NCBI Official Synonym Symbols: FPS; FPPS; POROK9
• NCBI Protein Information: farnesyl pyrophosphate synthase
• UniProt Protein Name: Farnesyl pyrophosphate synthase
• Protein Family: Farnesyl pyrophosphate synthase
• UniProt Gene Name: FDPS
• UniProt Synonym Gene Names: FPS; KIAA1293; FPP synthase; FPS
• UniProt Entry Name: FPPS_HUMAN

NCBI Description

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Uniprot Description

FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1; Transferase; Motility/polarity/chemotaxis; EC 2.5.1.10

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity; metal ion binding

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; viral reproduction