CREB3L2 blocking peptide

CREB3L2 Blocking Peptide

Cat. Num. AAA824320

• Gene Names: CREB3L2; BBF2H7
• Reactivity: Human
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: CREB3L2; CREB3L2 Blocking Peptide; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7; CREB3L2 blocking peptide

• Host: Synthetic
• Reactivity: Human
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 248

• Applicable Applications for CREB3L2 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for CREB3L2 blocking peptide

The peptide is used to block Anti-CREB3L2 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 359339005
• NCBI GeneID: 64764
• NCBI Accession #: NP_001240704.1
• NCBI GenBank Nucleotide #: NM_001253775.1
• UniProt Accession #: Q70SY1; Q6P454; Q6ZMR6
• Molecular Weight: 27,722 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 2
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3-like 2
• NCBI Official Symbol: CREB3L2
• NCBI Official Synonym Symbols: BBF2H7
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 2; TCAG_1951439; FUS/BBF2H7 protein; B-ZIB transcription factor; basic transcription factor 2; BBF2 human homolog on chromosome 7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L2
• UniProt Synonym Gene Names: BBF2H7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Entry Name: CR3L2_HUMAN

NCBI Description

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; cartilage development; chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter