Rabbit anti-Human, Mouse TP53INP2 Polyclonal Antibody | anti-TP53INP2 antibody

Anti-TP53INP2 Antibody

Cat. Num. AAA8242905

• Gene Names: TP53INP2; DOR; PINH; C20orf110; dJ1181N3.1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: TP53INP2; Polyclonal Antibody; Anti-TP53INP2 Antibody; C20orf110; DOR; PINH; Tumor protein p53-inducible nuclear protein 2; Diabetes and obesity-regulated gene; p53-inducible protein U; PIG-U; anti-TP53INP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of TP53INP2 protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
• Sequence Length: 220

• Applicable Applications for anti-TP53INP2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TP53INP2. The exact sequence is proprietary.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of TP53INP2 expression in SHSY5Y (A), HEK293T (B), mouse kidney (C) whole cell lysates.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of TP53INP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)

Related Product Information for anti-TP53INP2 antibody

Rabbit polyclonal antibody to TP53INP2

NCBI and Uniprot Product Information

• NCBI GI #: 32699566
• NCBI GeneID: 58476
• UniProt Accession #: Q8IXH6; Q5JX64; Q8IYL5; Q9NU00; A8K8S8; E1P5P6
• Molecular Weight: 23,980 Da
• NCBI Official Full Name: Tumor protein p53-inducible nuclear protein 2
• NCBI Official Synonym Full Names: tumor protein p53 inducible nuclear protein 2
• NCBI Official Symbol: TP53INP2
• NCBI Official Synonym Symbols: DOR; PINH; C20orf110; dJ1181N3.1
• NCBI Protein Information: tumor protein p53-inducible nuclear protein 2
• UniProt Protein Name: Tumor protein p53-inducible nuclear protein 2
• Protein Family: Tumor protein p53-inducible nuclear protein
• UniProt Gene Name: TP53INP2
• UniProt Synonym Gene Names: C20orf110; DOR; PINH; PIG-U
• UniProt Entry Name: T53I2_HUMAN

Uniprot Description

TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus; PML body

Molecular Function: protein binding; ubiquitin binding

Biological Process: autophagic vacuole formation; osteoblast differentiation; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; tissue homeostasis; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process