Western Blot (WB)
(Western blot analysis of ATP1A2 expression in K562 (A), HepG2 (B), NIH3T3 (C), mouse brain (D), COS7 (E) whole cell lysates.)
Rabbit ATP1A2 Polyclonal Antibody | anti-ATP1A2 antibody
Anti-ATP1A2 Antibody
Western Blot (WB)
(Western blot analysis of ATP1A2 expression in K562 (A), HepG2 (B), NIH3T3 (C), mouse brain (D), COS7 (E) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of ATP1A2 expression in K562 (A), HepG2 (B), NIH3T3 (C), mouse brain (D), COS7 (E) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
Uniprot Description
ATP1A2: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. Defects in ATP1A2 are the cause of familial hemiplegic migraine type 2 (FHM2). FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood 1 (AHC1). AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Protein type: Membrane protein, multi-pass; Hydrolase; Transporter, ion channel; EC 3.6.3.9; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: caveola; cytoplasm; cytosol; dendritic spine; endosome; intracellular membrane-bound organelle; membrane; myelin sheath; plasma membrane; sodium:potassium-exchanging ATPase complex; T-tubule
Molecular Function: ATP binding; ATPase activity; chaperone binding; drug binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity
Biological Process: adult locomotory behavior; ATP hydrolysis coupled proton transport; ATP metabolic process; cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; locomotion; negative regulation of heart contraction; negative regulation of striated muscle contraction; neurological control of breathing; neurotransmitter uptake; potassium ion import; potassium ion transport; reduction of cytosolic calcium ion concentration; regulation of blood pressure; regulation of glutamate uptake during transmission of nerve impulse; regulation of smooth muscle contraction; regulation of striated muscle contraction; regulation of synaptic transmission, glutamatergic; regulation of the force of heart contraction; regulation of vasoconstriction; response to nicotine; sodium ion transport; transmembrane transport; visual learning
Disease: Alternating Hemiplegia Of Childhood 1; Migraine, Familial Hemiplegic, 2
Research Articles on ATP1A2
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Product Notes
The ATP1A2 atp1a2 (Catalog #AAA8242530) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ATP1A2 Antibody reacts with Human, Mouse, Rat, Bovine, Monkey, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's ATP1A2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: (1/500 - 1/1000). Researchers should empirically determine the suitability of the ATP1A2 atp1a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP1A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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