Western Blot (WB)
(Western blot analysis of GCP6 expression in HeLa (A), NIH3T3 (B) whole cell lysates.)
Rabbit anti-Human, Mouse GCP6 Polyclonal Antibody | anti-TUBGCP6 antibody
Anti-GCP6 Antibody
Western Blot (WB)
(Western blot analysis of GCP6 expression in HeLa (A), NIH3T3 (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of GCP6 expression in HeLa (A), NIH3T3 (B) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GCP6 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GCP6 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]
Uniprot Description
GCP6: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Defects in TUBGCP6 are the cause of microcephaly with chorioretinopathy, autosomal recessive (MCPHCR). A syndrome characterized by microcephaly, cognitive impairment, underdeveloped retina and choroid, and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident during the first year of life. Belongs to the TUBGCP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 22q13.31-q13.33
Cellular Component: centrosome; cytosol; gamma-tubulin ring complex; membrane; microtubule; spindle pole body
Molecular Function: gamma-tubulin binding; microtubule binding; microtubule minus-end binding; structural constituent of cytoskeleton
Biological Process: centrosome duplication; cytoplasmic microtubule organization and biogenesis; G2/M transition of mitotic cell cycle; interphase microtubule nucleation by interphase microtubule organizing center; meiosis; microtubule nucleation; mitotic cell cycle
Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive 1
Research Articles on TUBGCP6
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Product Notes
The TUBGCP6 tubgcp6 (Catalog #AAA8242389) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GCP6 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GCP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the TUBGCP6 tubgcp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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