Western Blot (WB)
(Western blot analysis of Plakophilin 2 expression in Jurkat (A), HepG2 (B), HEK293T (C) whole cell lysates.)
Rabbit anti-Human, Rat Plakophilin 2 Polyclonal Antibody | anti-PKP2 antibody
Anti-Plakophilin 2 Antibody
Western Blot (WB)
(Western blot analysis of Plakophilin 2 expression in Jurkat (A), HepG2 (B), HEK293T (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Plakophilin 2 expression in Jurkat (A), HepG2 (B), HEK293T (C) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of Plakophilin 2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of Plakophilin 2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Description
plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 12p11
Cellular Component: adherens junction; cell junction; desmosome; integral to membrane; intercellular junction; intermediate filament; nucleoplasm; nucleus; plasma membrane
Molecular Function: alpha-catenin binding; intermediate filament binding; protein binding; protein complex scaffold; protein kinase C binding; sodium channel regulator activity
Biological Process: cell-cell adhesion; gap junction assembly; heart development; intermediate filament bundle assembly; lipid homeostasis; maintenance of organ identity; negative regulation of cell migration; negative regulation of cell proliferation; ventricular cardiac muscle morphogenesis
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Research Articles on PKP2
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Product Notes
The PKP2 pkp2 (Catalog #AAA8241836) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Plakophilin 2 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Plakophilin 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the PKP2 pkp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plakophilin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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