Western Blot (WB)
(Western blot analysis of MICU1 expression in MCF7 (A), mouse brain (B), rat brain (C) whole cell lysates.)
MICU1 Monoclonal Antibody | anti-MICU1 antibody
Anti-MICU1 Antibody
Western Blot (WB)
(Western blot analysis of MICU1 expression in MCF7 (A), mouse brain (B), rat brain (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of MICU1 expression in MCF7 (A), mouse brain (B), rat brain (C) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of MICU1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of MICU1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Uniprot Description
MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Mitochondrial; Calcium-binding
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: intracellular; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function: calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity
Biological Process: defense response; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; protein homooligomerization
Disease: Myopathy With Extrapyramidal Signs
Research Articles on MICU1
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Product Notes
The MICU1 micu1 (Catalog #AAA8241578) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-MICU1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MICU1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/1000 - 1/2000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the MICU1 micu1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MICU1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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