GHRH Blocking Peptide | GHRHR blocking peptide
GHRH Receptor Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
Uniprot Description
GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, multi-pass; Cell development/differentiation; Receptor, GPCR; GPCR, family 2; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule
Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; lactation; adenylate cyclase activation; cell maturation; response to glucocorticoid stimulus; regulation of protein metabolic process; determination of adult life span; positive regulation of multicellular organism growth; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; water homeostasis; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; somatotropin secreting cell development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; hormone metabolic process; regulation of steroid hormone receptor signaling pathway
Disease: Isolated Growth Hormone Deficiency, Type Ib
Research Articles on GHRHR
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Product Notes
The GHRHR ghrhr (Catalog #AAA822773) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GHRH Receptor Blocking Peptide reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's GHRH can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the GHRHR ghrhr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GHRH, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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