TXNDC17 sirna

TXNDC17 siRNA (Human)

Cat. Num. AAA8226133

• Gene Names: TXNDC17; TRP14; TXNL5
• Reactivity: Human
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: TXNDC17; TXNDC17 siRNA (Human); TXNL5; Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; TRP14; Protein 42-9-9; Thioredoxin-like protein 5; TXNDC17 sirna

• Host: Synthetic
• Reactivity: Human
• Specificity: TXNDC17 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 123

• Applicable Applications for TXNDC17 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human TXNDC17 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for TXNDC17 sirna

siRNA to inhibit TXNDC17 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 14249348
• NCBI GeneID: 84817
• NCBI Accession #: NP_116120.1
• NCBI GenBank Nucleotide #: NM_032731.3
• UniProt Accession #: Q9BRA2; A8K7E8
• Molecular Weight: 13,941 Da
• NCBI Official Full Name: thioredoxin domain-containing protein 17
• NCBI Official Synonym Full Names: thioredoxin domain containing 17
• NCBI Official Symbol: TXNDC17
• NCBI Official Synonym Symbols: TRP14; TXNL5
• NCBI Protein Information: thioredoxin domain-containing protein 17
• UniProt Protein Name: Thioredoxin domain-containing protein 17
• UniProt Gene Name: TXNDC17
• UniProt Synonym Gene Names: TXNL5; TRP14
• UniProt Entry Name: TXD17_HUMAN

Uniprot Description

TXNL5: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. Belongs to the thioredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytosol

Molecular Function: protein-disulfide reductase activity; protein binding; peroxidase activity; electron carrier activity

Biological Process: tumor necrosis factor-mediated signaling pathway