NFKBIL1 sirna

NFKBIL1 siRNA (Rat)

Cat. Num. AAA8223932

• Reactivity: Rat
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: NFKBIL1; NFKBIL1 siRNA (Rat); IKBL; NF-kappa-B inhibitor-like protein 1; Inhibitor of kappa B-like protein; I-kappa-B-like protein; IkappaBL; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1; NFKBIL1 sirna

• Host: Synthetic
• Reactivity: Rat
• Specificity: NFKBIL1 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 381

• Applicable Applications for NFKBIL1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat NFKBIL1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for NFKBIL1 sirna

siRNA to inhibit NFKBIL1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 47059201
• NCBI GeneID: 361794
• NCBI Accession #: NP_997674.1
• NCBI GenBank Nucleotide #: NM_212509.2
• UniProt Accession #: Q8R2H1; Q499T4
• Molecular Weight: 43,293 Da
• NCBI Official Full Name: NF-kappa-B inhibitor-like protein 1
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
• NCBI Official Symbol: Nfkbil1
• NCBI Protein Information: NF-kappa-B inhibitor-like protein 1
• UniProt Protein Name: NF-kappa-B inhibitor-like protein 1
• Protein Family: NF-kappa-B inhibitor-like protein
• UniProt Gene Name: Nfkbil1
• UniProt Synonym Gene Names: Ikbl; I-kappa-B-like protein; IkappaBL
• UniProt Entry Name: IKBL1_RAT

NCBI Description

human homolog is associated with susceptibility for rheumatoid arthritis [RGD, Feb 2006]

Uniprot Description

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli ().