ZAK Blocking Peptide | MLTK blocking peptide

ZAK Blocking Peptide

Cat. Num. AAA8219277

• Gene Names: ZAK; pk; AZK; MLT; MRK; MLK7; MLTK; mlklak
• Reactivity: Human, Mouse
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: ZAK; ZAK Blocking Peptide; MLTK; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK; MLTK blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 800

• Applicable Applications for MLTK blocking peptide: Blocking (BL)
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for MLTK blocking peptide

The peptide is used to block Anti-ZAK Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 82880648
• NCBI GeneID: 51776
• NCBI Accession #: NP_057737.2
• NCBI GenBank Nucleotide #: NM_016653.2
• UniProt Accession #: Q9NYL2; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; B3KPG2
• Molecular Weight: 35,468 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase MLT isoform 1
• NCBI Official Symbol: ZAK
• NCBI Official Synonym Symbols: pk; AZK; MLT; MRK; MLK7; MLTK; mlklak
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase MLT
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase MLT
• UniProt Gene Name: ZAK
• UniProt Synonym Gene Names: MLTK; HCCS-4; MLK-related kinase; MRK
• UniProt Entry Name: MLTK_HUMAN

NCBI Description

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding

Biological Process: cell death; cell proliferation; response to radiation; activation of MAPKK activity; positive regulation of apoptosis; DNA damage checkpoint; response to stress; cytoskeleton organization and biogenesis; cell cycle arrest; cell differentiation; cell cycle checkpoint; protein amino acid phosphorylation; activation of JNK activity