CTNND1 sirna

CTNND1 siRNA (Mouse)

Cat. Num. AAA8216667

• Gene Names: Ctnnd1; P120; Catns; Ctnnd; AA409437; AU019353; mKIAA0384
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: CTNND1; CTNND1 siRNA (Mouse); CATNS; KIAA0384; Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas; CTNND1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: CTNND1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 917

• Applicable Applications for CTNND1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse CTNND1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for CTNND1 sirna

siRNA to inhibit CTNND1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 146219835
• NCBI GeneID: 12388
• NCBI Accession #: NP_001078917.1
• NCBI GenBank Nucleotide #: NM_001085448.1
• UniProt Accession #: P30999; Q3TSU9; Q80XQ4; Q8CHF8
• Molecular Weight: 102,565 Da
• NCBI Official Full Name: catenin delta-1 isoform 2
• NCBI Official Synonym Full Names: catenin (cadherin associated protein), delta 1
• NCBI Official Symbol: Ctnnd1
• NCBI Official Synonym Symbols: P120; Catns; Ctnnd; AA409437; AU019353; mKIAA0384
• NCBI Protein Information: catenin delta-1
• UniProt Protein Name: Catenin delta-1
• Protein Family: Catenin
• UniProt Gene Name: Ctnnd1
• UniProt Synonym Gene Names: Catns; Kiaa0384; CAS; p120(ctn)
• UniProt Entry Name: CTND1_MOUSE

Uniprot Description

CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described.

Protein type: Adaptor/scaffold; Actin-binding; Motility/polarity/chemotaxis; G protein regulator, misc.; Cell adhesion

Cellular Component: tight junction; dendritic spine; zonula adherens; intercellular junction; cytosol; growth cone; cell-cell adherens junction; membrane; lamellipodium; cytoplasm; plasma membrane; synapse; midbody; nucleus

Molecular Function: protein domain specific binding; protein binding; cadherin binding; cell adhesion molecule binding; protein phosphatase binding; protein kinase binding; receptor binding

Biological Process: keratinocyte differentiation; cell-cell adhesion; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; salivary gland morphogenesis; cell adhesion; morphogenesis of a polarized epithelium