PSG6 recombinant protein

PSG6 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121544

• Gene Names: PSG6; PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12
• Purity: >87% as determined by SDS-PAGE
• Synonyms: PSG6; PSG6 Protein; Human; Recombinant (His Tag); Human PSG6/PSG10 Protein (His Tag); CGM3 Protein; PSBG-10 Protein; PSBG-12 Protein; PSBG-6 Protein; PSG10 Protein; PSG12 Protein; PSGGB Protein; pregnancy specific beta-1-glycoprotein 6; PSG6 recombinant protein

• Host: Baculovirus-Insect Cells
• Purity/Purification: >87% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-His424

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 35
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human PSG6 (Met 1-His 424)(NP_001027020) was expressed, with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for PSG6 recombinant protein

Background: PSG6 is a pregnancy-specific glycoprotein(PSG). PSGs are secreted proteins produced by the rodent and primate placenta and play a critical role in pregnancy success. The levels of PSGs are highest during the third trimester of pregnancy, a time marked by the most profound suppression of MS disease attacks. PSGs regulate T-cell function. The regulation of T-cell function during pregnancy is likely the result of significant hormonal changes and may well involve immunoregulatory proteins derived from the placenta. Pregnancy specific glycoproteins (PSGs) are the most abundant placentally derived glycoproteins in the maternal serum. PSG1, PSG6, PSG6N, and PSG11 induce dose-dependent secretion of anti-inflammatory cytokines by human monocytes. Human and murine PSGs exhibit cross-species activity.

References

Teglund S, et al. (1995) Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. Biochem Biophys Res Commun. 211(2):656-64.Grimwood J, et al.. (2004) The DNA sequence and biology of human chromosome 19. Nature. 428(6982):529-35.Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.

NCBI and Uniprot Product Information

• NCBI GI #: 73661174
• NCBI GeneID: 5675
• NCBI Accession #: NP_001027020
• NCBI GenBank Nucleotide #: NM_001031850.3
• UniProt Accession #: Q00889; O75244; Q15224; Q15235; Q549K1
• Molecular Weight: 47,501 Da
• NCBI Official Full Name: pregnancy-specific beta-1-glycoprotein 6 isoform b
• NCBI Official Synonym Full Names: pregnancy specific beta-1-glycoprotein 6
• NCBI Official Symbol: PSG6
• NCBI Official Synonym Symbols: PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12
• NCBI Protein Information: pregnancy-specific beta-1-glycoprotein 6
• UniProt Protein Name: Pregnancy-specific beta-1-glycoprotein 6
• Protein Family: Pregnancy-specific beta-1-glycoprotein
• UniProt Gene Name: PSG6
• UniProt Synonym Gene Names: CGM3; PSG10; PSG12; PSGGB; PS-beta-G-6; PSBG-6; Pregnancy-specific glycoprotein 6; PS-beta-G-10; PSBG-10; Pregnancy-specific glycoprotein 10; PS-beta-G-12; PSBG-12; Pregnancy-specific glycoprotein 12

NCBI Description

This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Description

PSG6: a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.31

Cellular Component: extracellular region

Biological Process: female pregnancy