Mouse anti-Rat IL1R2 Monoclonal Antibody | anti-IL1R2 antibody
Anti-IL1R2 Antibody, Mouse Monoclonal
Reactivity
Rat
Applications
ELISA, ELISA
Purity
Protein A
Synonyms
IL1R2; Monoclonal Antibody; Anti-IL1R2 Antibody; Mouse Monoclonal; IL-1R2/CD121b Antibody; Mouse MAb; interleukin 1 receptor; type II; anti-IL1R2 antibody
Host
Mouse
Reactivity
Rat
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
05
Specificity
Rat IL-1R2/CD121b.
No cross-reactivity in ELISA with Human IL1R2, Mouse IL1R2, Human IL1R3, Human IL1R8, Human IL1R9, Human IL1RA, Human IL1alpha, Human IL1beta, Human cell lysate (293 cell line)
No cross-reactivity in ELISA with Human IL1R2, Mouse IL1R2, Human IL1R3, Human IL1R8, Human IL1R9, Human IL1RA, Human IL1alpha, Human IL1beta, Human cell lysate (293 cell line)
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-IL1R2 antibody
ELISA (EIA), ELISA (EIA) (Det)
Application Notes
ELISA: 1:1000-1:2000
ELISA (Det): 1:1000-1:10,000
ELISA (Det): This antibody will detect Rat IL-1R2/CD121b in ELISA pair set.
In a sandwich ELISA, it can be used as detection antibody when paired with.
ELISA (Det): 1:1000-1:10,000
ELISA (Det): This antibody will detect Rat IL-1R2/CD121b in ELISA pair set.
In a sandwich ELISA, it can be used as detection antibody when paired with.
Immunogen
Recombinant Rat IL-1R2/CD121b protein
Conjugation
Unconjugated
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL-1R2/CD121b. The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-IL1R2 antibody
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate the development and maintenance of the inflammatory responses and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors that can bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand-binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes, and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
Product Categories/Family for anti-IL1R2 antibody
References
Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,353 Da
NCBI Official Full Name
interleukin-1 receptor type 2
NCBI Official Synonym Full Names
interleukin 1 receptor type 2
NCBI Official Symbol
Il1r2
NCBI Protein Information
interleukin-1 receptor type 2
UniProt Protein Name
Interleukin-1 receptor type 2
Protein Family
UniProt Gene Name
Il1r2
UniProt Synonym Gene Names
Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII
NCBI Description
receptor for IL-1 alpha and IL-1 beta [RGD, Feb 2006]
Uniprot Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors ().
Research Articles on IL1R2
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Product Notes
The IL1R2 il1r2 (Catalog #AAA8112802) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL1R2 Antibody, Mouse Monoclonal reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL1R2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), ELISA (EIA) (Det). ELISA: 1:1000-1:2000 ELISA (Det): 1:1000-1:10,000 ELISA (Det): This antibody will detect Rat IL-1R2/CD121b in ELISA pair set. In a sandwich ELISA, it can be used as detection antibody when paired with. Researchers should empirically determine the suitability of the IL1R2 il1r2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1R2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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