Rabbit anti-Rat GM-CSF Polyclonal Antibody | anti-CSF2 antibody

Anti-GM-CSF Antibody, Rabbit Polyclonal

Cat. Num. AAA8112619

• Gene Names: Csf2; Gmcsf; Gm-csf
• Reactivity: Rat
• Applications: ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: GM-CSF; Polyclonal Antibody; Anti-GM-CSF Antibody; Rabbit Polyclonal; GM-CSF/CSF2 Antibody; Rabbit PAb; Antigen Affinity Purified; colony stimulating factor 2 (granulocyte-macrophage); anti-CSF2 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Rat GM-CSF/CSF2
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CSF2 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Immunogen: Recombinant Rat GM-CSF/CSF2 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Rat GM-CSF/CSF2. GM-CSF/CSF2 specific IgG was purified by Rat GM-CSF/CSF2 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CSF2 antibody

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.

Product Categories/Family for anti-CSF2 antibody

Cancer Drug Targets; IL17 signaling pathway

References

Robertson SA. (2007) GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-98.
Waller EK. (2007) The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12 Suppl 2: 22-6.
Clive KS, et al. (2010) Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 9(5): 519-25.

NCBI and Uniprot Product Information

• NCBI GI #: 449083355
• NCBI GeneID: 116630
• NCBI Accession #: NP_446304.1
• NCBI GenBank Nucleotide #: NP_446304.1
• UniProt Accession #: P48750
• NCBI Official Full Name: granulocyte-macrophage colony-stimulating factor
• NCBI Official Synonym Full Names: colony stimulating factor 2
• NCBI Official Symbol: Csf2
• NCBI Official Synonym Symbols: Gmcsf; Gm-csf
• NCBI Protein Information: granulocyte-macrophage colony-stimulating factor
• UniProt Protein Name: Granulocyte-macrophage colony-stimulating factor
• Protein Family: Granulocyte-macrophage colony-stimulating factor
• UniProt Gene Name: Csf2
• UniProt Synonym Gene Names: Csfgm; GM-CSF; CSF
• UniProt Entry Name: CSF2_RAT

NCBI Description

plays a role in alveolar epithelial fluid transport [RGD, Feb 2006]

Uniprot Description

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Cellular Component: extracellular space

Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; positive regulation of interleukin-23 production; myeloid dendritic cell differentiation; regulation of cell proliferation; epithelial cell proliferation; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of cell proliferation; immune response; positive regulation of macrophage differentiation; positive regulation of DNA replication