Rabbit anti-Human PPARGC1A/PGC1 Polyclonal Antibody | anti-PPARGC1A antibody
Anti-PPARGC1A/PGC1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunocytochemistry, Immunofluorescence
Purity
Protein A & Antigen Affinity
Synonyms
PPARGC1A/PGC1; Polyclonal Antibody; Anti-PPARGC1A/PGC1 Antibody; Rabbit Polyclonal; PPARGC1A/PGC1 Antibody; Rabbit PAb; Antigen Affinity Purified; peroxisome proliferator-activated receptor gamma; coactivator 1 alpha; Anti-LEM6 Antibody; Anti-PGC-1(alpha) Antibody; Anti-PGC-1v Antibody; Anti-PGC1 Antibody; Anti-PGC1A Antibody; Anti-PPARGC1 Antibody; anti-PPARGC1A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human PPARGC1A/PGC1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-PPARGC1A antibody
Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes
ICC/IF: 1:100-1:500
Immunogen
E Coli-derived Human PPARGC1A/PGC1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human PPARGC1A/PGC1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-PPARGC1A antibody
Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC1alpha) encoded by the PPARGC1A gene is a vital regulator of glucose and fatty acid oxidation, mitochondrial biogenesis, and skeletal muscle fiber conversion. PGC-1alpha is a transcriptional co-activator that has been implicated in the pathogenesis of neurodegenerative disorders. As a central regulator of mitochondrial biogenesis and metabolism, PPARGC1A acts as a powerful coactivator of many transcriptional factors that relate to steroidogenesis. The mitochondrial regulator PPARGC1A regulates mitochondrial biogenesis, reducing senescence of vascular smooth muscle cells (VSMCs). PPARGC1A upregulates autophagy reducing senescence by an SQSTM1-dependent mechanism. Evaluation in human normal lung and metastatic lung cancer cell lines revealed that the expression of PPARGC1A was upregulated in metastatic lung cancer cell lines.
Product Categories/Family for anti-PPARGC1A antibody
References
Zhang GM, et al. (2019) Effect of ppargc1a on the development and metabolism of early rabbit embryos in vitro. Mol Reprod Dev 86 (11): 1758-1770.Salazar G, et al. (2020) Sqstm1/p62 and ppargc1a/pgc-1alpha at the interface of autophagy and vascular senescence. Autophagy 16 (6): 1092-1110.Li JD, et al. (2017) Ppargc1a is upregulated and facilitates lung cancer metastasis. Exp Cell Res 359 (2): 356-360.Chen Y, et al. (2019) Meta-analyses of the association between the ppargc1a gly482ser polymorphism and athletic performance. Biol Sport 36 (4): 301-309.
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Product Notes
The PPARGC1A (Catalog #AAA8110360) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PPARGC1A/PGC1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PPARGC1A/PGC1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF). ICC/IF: 1:100-1:500. Researchers should empirically determine the suitability of the PPARGC1A for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPARGC1A/PGC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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