Western Blot (WB)
(Anti-SLC34A1 rabbit polyclonal antibody at 1:500 dilution Lane A: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:69 kDa Observed band size:69 kDa)
Rabbit anti-Human SLC34A1 Polyclonal Antibody | anti-SLC34A1 antibody
Anti-SLC34A1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Western Blot, Immunocytochemistry, Immunofluorescence
Purity
Protein A & Antigen Affinity
Synonyms
SLC34A1; Polyclonal Antibody; Anti-SLC34A1 Antibody; Rabbit Polyclonal; SLC34A1 Antibody; Rabbit PAb; Antigen Affinity Purified; solute carrier family 34 (sodium phosphate); member 1; Anti-FRTS2 Antibody; Anti-NAPI-3 Antibody; Anti-NPHLOP1 Antibody; Anti-NPT2 Antibody; Anti-NPTIIa Antibody; Anti-SLC11 Antibody; Anti-SLC17A2 Antibody; anti-SLC34A1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human SLC34A1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-SLC34A1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
ICC/IF: 1:100-1:500
ICC/IF: 1:100-1:500
Immunogen
E Coli-derived Human SLC34A1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human SLC34A1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Western Blot (WB)
(Anti-SLC34A1 rabbit polyclonal antibody at 1:500 dilution Lane A: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:69 kDa Observed band size:69 kDa)
Western Blot (WB)
(Anti-SLC34A1 rabbit polyclonal antibody at 1:500 dilution Lane A: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:69 kDa Observed band size:69 kDa)
Related Product Information for anti-SLC34A1 antibody
Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Slc34a1 resides downstream of the gene encoding coagulation factor XII (f12). The Na+-dependent phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in the kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with prominent expression in the lung and small intestine. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal derangements associated with increased cardiovascular risk in chronic kidney disease-mineral and bone disorder (CKD-MBD). Mutations in SLC34A1 may cause a range of clinical phenotypes including and idiopathic infantile hypercalcemia and nephrocalcinosis, a proximal renal Fanconi syndrome, which are typically autosomal recessive, and hypophosphatemic nephrolithiasis, which may be an autosomal dominant trait.
References
Kurnaz E, et al. (2019) Rare cause of infantile hypercalcemia: A novel mutation in the slc34a1 gene. Horm Res Paediatr 91 (4): 278-284.Iwaki T, et al. (2008) A missense mutation in the sodium phosphate co-transporter slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol 19 (9): 1753-1762.Filipski KJ, et al. (2018) Discovery of orally bioavailable selective inhibitors of the sodium-phosphate cotransporter napi2a (slc34a1). ACS Med Chem Lett 9 (5): 440-445.Fearn A, et al. (2018) Clinical, biochemical, and pathophysiological analysis of slc34a1 mutations. Physiol Rep 6 (12): e13715.
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Product Notes
The SLC34A1 (Catalog #AAA8108575) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SLC34A1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC34A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF). WB: 1:500-1:2000 ICC/IF: 1:100-1:500. Researchers should empirically determine the suitability of the SLC34A1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC34A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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