Mouse anti-Human LILRB3 Monoclonal Antibody | anti-LILRB3 antibody

Anti-LILRB3 Antibody (PE), Mouse Monoclonal

Cat. Num. AAA8106076

• Gene Names: LILRB3; HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: LILRB3; Monoclonal Antibody; Anti-LILRB3 Antibody (PE); Mouse Monoclonal; LILRB3 Antibody (PE); Mouse MAb; leukocyte immunoglobulin like receptor B3; Anti-CD85A Antibody; Anti-HL9 Antibody; Anti-ILT-5 Antibody; Anti-ILT5 Antibody; Anti-LILRA6 Antibody; Anti-LIR-3 Antibody; Anti-LIR3 Antibody; Anti-MGC138403 Antibody; Anti-PIRB Antibody; Anti-XXbac-BCX105G6.7 Antibody; anti-LILRB3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 08
• Specificity: Human LILRB3
• Purity/Purification: Protein A
• Form/Format: Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
• Concentration: 5ul/Test, 0.1mg/ml (varies by lot)

• Applicable Applications for anti-LILRB3 antibody: Flow Cytometry (FC/FACS/FCM)
• Immunogen: Recombinant Human LILRB3 Protein
• Conjugation: PE
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LILRB3 (rh LILRB3) and conjugated with PE under optimum conditions, the unreacted PE was removed.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of anti-human GM-CSFRa(CD116) on human peripheral blood monocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes.)

Related Product Information for anti-LILRB3 antibody

Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3/CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3/CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3/CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.

Product Categories/Family for anti-LILRB3 antibody

ITIM/ITAM Immunoreceptors and Related Molecules

References

Huang, J. et al., 2010, J Virol. 84 (18): 9463-71. Arm J.P. et al., 1997, J. Immunol. 159:2342-2349. Wende H. et al., 2000, Immunogenetics 51:703-713. Yu L.-R. et al., 2007, J. Proteome Res. 6:4150-4162.

NCBI and Uniprot Product Information

• NCBI GI #: 125661045
• NCBI GeneID: 11025
• NCBI Accession #: NP_006855.2
• NCBI GenBank Nucleotide #: NM_006864.2
• UniProt Accession #: O75022; O15471; Q86U49; C9J1P3; C9JIP1
• Molecular Weight: 69,514 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor B3
• NCBI Official Symbol: LILRB3
• NCBI Official Synonym Symbols: HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 3
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 3
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRB3
• UniProt Synonym Gene Names: ILT5; LIR3; LIR-3; Leukocyte immunoglobulin-like receptor 3; ILT-5
• UniProt Entry Name: LIRB3_HUMAN

NCBI Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LILRB3: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; receptor activity; transmembrane receptor activity

Biological Process: adaptive immune response; cell surface receptor linked signal transduction; defense response; negative regulation of osteoclast differentiation