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Rabbit anti-Human DMBT1 Polyclonal Antibody | anti-DMBT1 antibody

Anti-DMBT1 Antibody, Rabbit Polyclonal

Gene Names
DMBT1; GP340; muclin
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
DMBT1; Polyclonal Antibody; Anti-DMBT1 Antibody; Rabbit Polyclonal; DMBT1/Muclin Antibody; Rabbit PAb; deleted in malignant brain tumors 1; Anti-GP340 Antibody; Anti-muclin Antibody; anti-DMBT1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human DMBT1/GP340
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-DMBT1 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000-1:2000
Immunogen
Recombinant Human DMBT1 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human DMBT1 (rh DMBT1). Total IgG was purified by Protein A affinity chromatography .
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-DMBT1 antibody
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.
References
Mollenhauer J., et al., (1997), DMBT1, a new member of the SRCR superfamily on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours. Nat. Genet. 17:32-39.Holmskov U., et al., (1999), Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.Proc. Natl. Acad. Sci. U.S.A. 96:10794-10799.Mollenhauer J., et al., (1999), The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.Oncogene 18:6233-6240.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
260,735 Da
NCBI Official Full Name
deleted in malignant brain tumors 1 protein isoform a
NCBI Official Synonym Full Names
deleted in malignant brain tumors 1
NCBI Official Symbol
DMBT1
NCBI Official Synonym Symbols
GP340; muclin
NCBI Protein Information
deleted in malignant brain tumors 1 protein; SAG; gp-340; hensin; glycoprotein 340; salivary agglutinin; surfactant pulmonary-associated D-binding protein
UniProt Protein Name
Deleted in malignant brain tumors 1 protein
UniProt Gene Name
DMBT1
UniProt Synonym Gene Names
GP340; Gp-340; SAG

Uniprot Description

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

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Product Notes

The DMBT1 dmbt1 (Catalog #AAA8105608) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DMBT1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DMBT1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000. Researchers should empirically determine the suitability of the DMBT1 dmbt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DMBT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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