Mouse anti-Human CD200RLa Monoclonal Antibody | anti-CD200R1L antibody

Anti-CD200RLa Antibody, Mouse Monoclonal

Cat. Num. AAA8105523

• Reactivity: Human
• Applications: ELISA, ELISA
• Purity: Protein A
• Synonyms: CD200RLa; Monoclonal Antibody; Anti-CD200RLa Antibody; Mouse Monoclonal; CD200RLa/CD200R1L Antibody; Mouse MAb; CD200 receptor 1 like; Anti-CD200R2 Antibody; anti-CD200R1L antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 6D6C1
• Specificity: Human CD200RLa/CD200R1L.; No cross-reactivity in ELISA with Human cell lysate (293 cell line)
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CD200R1L antibody: ELISA (EIA), ELISA (EIA) (Det)
• Application Notes: ELISA: 1:1000-1:2000; ELISA (Det): 1:1000-1:10,000; ELISA (Det): This antibody will detect Human CD200RLa in ELISA pair set.; In a sandwich ELISA, it can be used as detection antibody when paired with.
• Immunogen: Recombinant Human CD200RLa/CD200R1L protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD200RLa/CD200R1L (rh CD200RLa/CD200R1L). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD200R1L antibody

Cell surface glycoprotein CD2 receptor 2, also known as Cell surface glycoprotein CD2 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD2 receptor-like 2, CD2Rla, CD2R1L and CD2R2, is a single-pass type I membrane protein which belongs to theCD2R family. CD2R1L/CD2R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD2 is a transmembrane protein delivering immunoregulatory signals after engagement of CD2R. A family of CD2Rs exist (CD2R1, CD2R2, CD2R3, CD2R4) with different tissue expression and functional activity. In the presence of anti-CD2R2/CD2R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD2 and one of its receptors, CD2R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD2R1, anti-CD2R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.

References

Wright G.J., et al., (2003), Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171:3034-3046.Gorczynski R.M., et al., (2004), Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface.Am. J. Reprod. Immunol. 52:147-163.Muzny D.M., et al., (2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.

NCBI and Uniprot Product Information

• Protein Family: Cell surface glycoprotein CD200 receptor