Mouse anti-Human TREM-2 Monoclonal Antibody | anti-TREM2 antibody

Anti-TREM-2 Antibody, Mouse Monoclonal

Cat. Num. AAA8104833

• Gene Names: TREM2; TREM-2; Trem2a; Trem2b; Trem2c
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: TREM-2; Monoclonal Antibody; Anti-TREM-2 Antibody; Mouse Monoclonal; TREM-2/TREM2 Antibody; Mouse MAb; triggering receptor expressed on myeloid cells 2; Anti-Trem2a Antibody; Anti-Trem2b Antibody; Anti-Trem2c Antibody; anti-TREM2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 08
• Specificity: Human TREM-2/TREM2
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-TREM2 antibody: ELISA (EIA) (Det)
• Application Notes: ELISA (Det): This antibody will detect Human TREM-2/TREM2 in ELISA pair set.; In a sandwich ELISA, it can be used as detection antibody when paired with.
• Immunogen: Recombinant Human TREM-2/TREM2 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-2/TREM2 (rh TREM-2/TREM2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-TREM2 antibody

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

References

Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995. Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48. Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9. Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.

NCBI and Uniprot Product Information

• NCBI GI #: 9507203
• NCBI GeneID: 54209
• NCBI Accession #: NP_061838.1
• NCBI GenBank Nucleotide #: NM_018965.3
• Molecular Weight: 24,669 Da
• NCBI Official Full Name: triggering receptor expressed on myeloid cells 2 isoform 1
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells 2
• NCBI Official Symbol: TREM2
• NCBI Official Synonym Symbols: TREM-2; Trem2a; Trem2b; Trem2c
• NCBI Protein Information: triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
• Protein Family: Triggering receptor expressed on myeloid cells

NCBI Description

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]