Rabbit anti-Human GPRIN1 Polyclonal Antibody | anti-GPRIN1 antibody

Anti-GPRIN1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102223

• Gene Names: GPRIN1; GRIN1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: GPRIN1; Polyclonal Antibody; Anti-GPRIN1 Antibody; Rabbit Polyclonal; GPRIN1 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-GRIN1 Antibody; anti-GPRIN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human GPRIN1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-GPRIN1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:1000-1:4000
• Immunogen: A synthetic peptide corresponding to the center region of the Human GPRIN1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human GPRIN1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human GPRIN1 in human brain with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-GPRIN1 antibody

GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) gene encodes Glutamate [NMDA] receptor subunit zeta-1 protein. GPRIN1 are associated with diseases such as Cerebral Creatine Deficiency Syndrome 2 and Gastric Small Cell Carcinoma. The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.

References

Monyer H, et al. (1992) Heteromeric nmda receptors: Molecular and functional distinction of subtypes. Science 256 (5060): 1217-1221.

NCBI and Uniprot Product Information

• NCBI GI #: 112821681
• NCBI GeneID: 114787
• NCBI Accession #: NP_443131.2
• NCBI GenBank Nucleotide #: NM_052899.2
• UniProt Accession #: Q7Z2K8; Q8ND74; Q96PZ4; C9JM70
• Molecular Weight: 102,399 Da
• NCBI Official Full Name: G protein-regulated inducer of neurite outgrowth 1
• NCBI Official Synonym Full Names: G protein regulated inducer of neurite outgrowth 1
• NCBI Official Symbol: GPRIN1
• NCBI Official Synonym Symbols: GRIN1
• NCBI Protein Information: G protein-regulated inducer of neurite outgrowth 1
• UniProt Protein Name: G protein-regulated inducer of neurite outgrowth 1
• Protein Family: G protein-regulated inducer of neurite outgrowth
• UniProt Gene Name: GPRIN1
• UniProt Synonym Gene Names: KIAA1893; GRIN1
• UniProt Entry Name: GRIN1_HUMAN

Uniprot Description

GRIN1: May be involved in neurite outgrowth. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: growth cone; plasma membrane

Molecular Function: phosphoprotein binding

Biological Process: neurite development