Mouse anti-Human CD84 Monoclonal Antibody | anti-CD84 antibody

Anti-CD84 Antibody, Mouse Monoclonal

Cat. Num. AAA8100871

• Gene Names: CD84; LY9B; hCD84; mCD84; SLAMF5
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: CD84; Monoclonal Antibody; Anti-CD84 Antibody; Mouse Monoclonal; CD84 Antibody; Mouse MAb; CD84 molecule; Anti-hCD84 Antibody; Anti-LY9B Antibody; Anti-mCD84 Antibody; Anti-SLAMF5 Antibody; anti-CD84 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: 05
• Specificity: Human CD84
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CD84 antibody: ELISA (EIA) (Det)
• Application Notes: ELISA (Det): This antibody will detect Human CD84 in ELISA pair set.; In a sandwich ELISA, it can be used as detection antibody when paired with.
• Immunogen: Recombinant Human CD84 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD84 (rh CD84). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD84 antibody

The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

Product Categories/Family for anti-CD84 antibody

ITIM/ITAM Immunoreceptors and Related Molecules

References

Martin M, et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 167(7): 3668-76.Tangye SG, et al. (2002) CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Eur J Immunol. 32(6): 1640-9.Zaiss M, et al. (2003) CD84 expression on human hematopoietic progenitor cells. Exp Hematol. 31(9): 798-805.Tangye SG, et al. (2003) Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J Immunol. 171(5): 2485-95.Yan Q, et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A. 104(25): 10583-8.

NCBI and Uniprot Product Information

• NCBI GI #: 4502687
• NCBI GeneID: 8832
• NCBI Accession #: NP_003865.1
• NCBI GenBank Nucleotide #: NM_003874.3
• UniProt Accession #: Q9UIB8; O15430; O95266; O95660; Q5H9R1; Q6FHA8; Q8WLP1; Q8WWI8; Q9UF04; Q9UIB6; B2R8T1; B7Z3R8
• Molecular Weight: 24,025 Da
• NCBI Official Full Name: SLAM family member 5 isoform 2
• NCBI Official Synonym Full Names: CD84 molecule
• NCBI Official Symbol: CD84
• NCBI Official Synonym Symbols: LY9B; hCD84; mCD84; SLAMF5
• NCBI Protein Information: SLAM family member 5
• UniProt Protein Name: SLAM family member 5
• Protein Family: SLAM family
• UniProt Gene Name: CD84
• UniProt Synonym Gene Names: SLAMF5
• UniProt Entry Name: SLAF5_HUMAN

NCBI Description

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Uniprot Description

CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Cell surface; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: defense response; homophilic cell adhesion; blood coagulation; leukocyte migration