Chemical Structure
(Chemical structure of Thapsigargin (SIH-399), a Autophagy inhibitor. CAS #: 67526-95-8. Molecular Formula: C34H50O12. Molecular Weight: 650.8 g/mol.)
Thapsigargin Small Molecule
Thapsigargin
Purity
>=95%
Synonyms
Thapsigargin; Autophagy inhibitor; (3S; 3aR; 4S; 6S; 6AR; 7S; 8S; 9bS)-6- (Acetyloxy)-2; 3; 3a; 4; 5; 6; 6a; 7; 8; 9b-decahydro-3; 3a-dihydroxy-3; 9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4; 5-b]furan-7-yl octanoate; Thapsigargin small molecule
Host
Synthetic
Purity/Purification
>=95%
Form/Format
Colorless wax or white solid.
Solubility
Soluble in DMSO (20 mg/ml), 100% ethanol (20 mg/ml) or acetone.
CAS Number
67526-95-8
Molecular Formula
C34H50O12
SMILES
[C@@H]13C(=C([C@H](OC(=O)C(=C\C)/C)[C@H]1OC(=O)CCCCCCC)C)[C@@H]2OC(=O)[C@@](O)([C@@]2(O)[C@@H](OC(=O)CCC)C[C@@]3(OC(=O)C)C)
InChI
1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChI Key
IXFPJGBNCFXKPI-FSIHEZPISA-N
PubChem CID
446378
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Thapsigargin (SIH-399), a Autophagy inhibitor. CAS #: 67526-95-8. Molecular Formula: C34H50O12. Molecular Weight: 650.8 g/mol.)
Chemical Structure
(Chemical structure of Thapsigargin (SIH-399), a Autophagy inhibitor. CAS #: 67526-95-8. Molecular Formula: C34H50O12. Molecular Weight: 650.8 g/mol.)
Related Product Information for Thapsigargin small molecule
Thapsigargin is a cell-permeable inhibitor of the sarco-endoplasmatic reticulum Ca2+-ATPase (SERCA). This inhibition causes the release of intracellular Ca2+ stores. Thapsigargin also inhibits autophagy. This is due to the induction of and an ER stress response, which causes downstream effects that include an accumulation of autophagosomes in the cytosol. These intermediate structures never mature into amphisomes and autolysosomes, and the autophagy process cannot be completed.
Product Categories/Family for Thapsigargin small molecule
References
1. Canová N.K., et al. (2007) Cell Biol Toxicol. 23(5): 337-54. 2. Ganley I.G., et al. (2011) Autophagy. 7(11): 1397-9. 3. Cheng Y., et al. (2013) Autophagy. 9(2): 208-19.
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Product Notes
The Thapsigargin (Catalog #AAA808103) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Thapsigargin, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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