Western Blot (WB)
(Western blot analysis of Human, Rat Brain cell lysates showing detection of BVR protein using Rabbit Anti-BVR Polyclonal Antibody (SPC-214). Lane 1: Rat Brain. Lane 2: Human Brain lysates. Load: 10 ug. Primary Antibody: Rabbit Anti-BVR Polyclonal Antibody (SPC-214) at 1:1000.)
Rabbit anti-Human BVR Polyclonal Antibody | anti-BLVRA antibody
BVR Antibody: ATTO 488
Western Blot (WB)
(Western blot analysis of Human, Rat Brain cell lysates showing detection of BVR protein using Rabbit Anti-BVR Polyclonal Antibody (SPC-214). Lane 1: Rat Brain. Lane 2: Human Brain lysates. Load: 10 ug. Primary Antibody: Rabbit Anti-BVR Polyclonal Antibody (SPC-214) at 1:1000.)
Western Blot (WB)
(Western blot analysis of Human, Rat Brain cell lysates showing detection of BVR protein using Rabbit Anti-BVR Polyclonal Antibody (SPC-214). Lane 1: Rat Brain. Lane 2: Human Brain lysates. Load: 10 ug. Primary Antibody: Rabbit Anti-BVR Polyclonal Antibody (SPC-214) at 1:1000.)
Scientific Background: Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
Protein type: Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); EC 1.3.1.24; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; ATYPICAL group; BLVRA family
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: cytosol
Molecular Function: zinc ion binding; biliverdin reductase activity
Biological Process: heme catabolic process; porphyrin metabolic process
Disease: Hyperbiliverdinemia
Research Articles on BLVRA
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Product Notes
The BLVRA blvra (Catalog #AAA805004) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BVR Antibody: ATTO 488 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BVR can be used in a range of immunoassay formats including, but not limited to, Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). 1:2000 (WB), 1:100 (IP). Researchers should empirically determine the suitability of the BLVRA blvra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BVR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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