Rabbit GTF2H5 Polyclonal Antibody | anti-GTF2H5 antibody

GTF2H5 Rabbit Polyclonal

Cat. Num. AAA769947

• Gene Names: GTF2H5; TTD; TFB5; TTD3; TTDA; TFIIH; TTD-A; TGF2H5; C6orf175; bA120J8.2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GTF2H5; Polyclonal Antibody; GTF2H5 Rabbit Polyclonal; anti-GTF2H5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 71

• Applicable Applications for anti-GTF2H5 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: General transcription factor IIH, polypeptide 5
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS769947 (GTF2H5 antibody) at dilution of 1:50)

NCBI and Uniprot Product Information

• NCBI GI #: 823672560
• NCBI GeneID: 404672
• Molecular Weight: 8,053 Da
• NCBI Official Full Name: GTF2H5, partial
• NCBI Official Synonym Full Names: general transcription factor IIH subunit 5
• NCBI Official Symbol: GTF2H5
• NCBI Official Synonym Symbols: TTD; TFB5; TTD3; TTDA; TFIIH; TTD-A; TGF2H5; C6orf175; bA120J8.2
• NCBI Protein Information: general transcription factor IIH subunit 5
• UniProt Protein Name: General transcription factor IIH subunit 5
• Protein Family: General transcription factor
• UniProt Gene Name: GTF2H5
• UniProt Synonym Gene Names: C6orf175; TTDA
• UniProt Entry Name: TF2H5_HUMAN

NCBI Description

This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A. [provided by RefSeq, Mar 2009]

Uniprot Description

GTF2H5: Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. Defects in GTF2H5 are a cause of trichothiodystrophy photosensitive (TTDP). TTDP is an autosomal recessive disease characterized by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect. Neonates with trichothiodystrophy and ichthyosis are usually born with a collodion membrane. The severity of the ichthyosis after the membrane is shed is variable, ranging from a mild to severe lamellar ichthyotic phenotype. There are no reports of skin cancer associated with TTDP. Belongs to the TFB5 family.

Protein type: DNA repair, damage; DNA-binding

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: nucleolus; nucleoplasm

Molecular Function: rDNA binding

Biological Process: mRNA capping; nucleotide-excision repair; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; rRNA processing; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair

Disease: Trichothiodystrophy 3, Photosensitive