Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS769475 (FUS/TLS Antibody) at dilution of 1:1000)
Mouse anti-Human, Mouse FUS/TLS Monoclonal Antibody | anti-FUS/TLS antibody
FUS/TLS Mouse Monoclonal
Purification: Protein A+G purification
Purification: Protein A+G purification
IP: 1:5000-1:50000
IHC: 1:500-1:2500
IF: 1:20-1:200
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS769475 (FUS/TLS Antibody) at dilution of 1:1000)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS769475 (FUS/TLS Antibody) at dilution of 1:1000)
Western Blot (WB)
(K-562 cells were subjected to SDS PAGE followed by western blot with MBS769475 (FUS antibody) at dilution of 1:1000)
Western Blot (WB)
(K-562 cells were subjected to SDS PAGE followed by western blot with MBS769475 (FUS antibody) at dilution of 1:1000)
Testing Data
(IP Result of anti-FUS/TLS (IP: MBS769475, 4ug; Detection: MBS769475 1:10000) with HeLa cells lysate 920ug.)
Testing Data
(IP Result of anti-FUS/TLS (IP: MBS769475, 4ug; Detection: MBS769475 1:10000) with HeLa cells lysate 920ug.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Uniprot Description
hnRNP P2: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Ubiquitous. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Oncoprotein; RNA-binding; Nuclear receptor co-regulator; DNA-binding
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; polysome
Molecular Function: DNA binding; estrogen receptor binding; identical protein binding; ionotropic glutamate receptor binding; myosin V binding; nucleotide binding; protein binding; retinoid X receptor binding; RNA binding; thyroid hormone receptor binding; transcription coactivator activity; zinc ion binding
Biological Process: nuclear mRNA splicing, via spliceosome
Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4
Research Articles on FUS/TLS
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Product Notes
The FUS/TLS fus (Catalog #AAA769475) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FUS/TLS Mouse Monoclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FUS/TLS can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP). WB: 1:500-1:2000 IP: 1:5000-1:50000 IHC: 1:500-1:2500 IF: 1:20-1:200. Researchers should empirically determine the suitability of the FUS/TLS fus for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FUS/TLS, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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