Rabbit anti-Human, Mouse FBXO7 Polyclonal Antibody | anti-FBXO7 antibody

FBXO7 Rabbit Polyclonal

Cat. Num. AAA769281

• Gene Names: FBXO7; FBX; FBX7; PKPS; FBX07; PARK15
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FBXO7; Polyclonal Antibody; FBXO7 Rabbit Polyclonal; anti-FBXO7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 443

• Applicable Applications for anti-FBXO7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: F-box protein 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS769281 (FBXO7 antibody) at dilution of 1:100)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS769281 (FBXO7 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 74229029
• NCBI GeneID: 25793
• NCBI Accession #: NP_001028196.1
• NCBI GenBank Nucleotide #: NM_001033024.1
• Molecular Weight: 45,781 Da
• NCBI Official Full Name: F-box only protein 7 isoform 2
• NCBI Official Synonym Full Names: F-box protein 7
• NCBI Official Symbol: FBXO7
• NCBI Official Synonym Symbols: FBX; FBX7; PKPS; FBX07; PARK15
• NCBI Protein Information: F-box only protein 7
• UniProt Protein Name: F-box only protein 7
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO7
• UniProt Synonym Gene Names: FBX7
• UniProt Entry Name: FBX7_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXO7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15); also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus; protein complex; ubiquitin ligase complex

Molecular Function: protein binding; protein kinase binding; ubiquitin-protein ligase activity

Biological Process: mitochondrion degradation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of lymphocyte differentiation; protein targeting to mitochondrion; protein ubiquitination; regulation of protein stability; ubiquitin-dependent protein catabolic process

Disease: Parkinson Disease 15, Autosomal Recessive Early-onset