Mouse FAF1 Monoclonal Antibody | anti-FAF1 antibody
FAF1 Mouse Monoclonal
Protein A+G purification
Protein A+G purification
NCBI and Uniprot Product Information
NCBI Description
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Uniprot Description
FAF1: a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: cytosol; nucleus; perinuclear region of cytoplasm
Molecular Function: heat shock protein binding; NF-kappaB binding; protein binding; protein kinase binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: cell death; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; regulation of protein catabolic process