Rabbit CNOT7 Polyclonal Antibody | anti-CNOT7 antibody

CNOT7 Rabbit Polyclonal

Cat. Num. AAA768043

• Gene Names: CNOT7; CAF1; CAF-1; Caf1a; hCAF-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CNOT7; Polyclonal Antibody; CNOT7 Rabbit Polyclonal; anti-CNOT7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 256

• Applicable Applications for anti-CNOT7 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: CCR4-NOT transcription complex, subunit 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Testing Data

()

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS768043 (CNOT7 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 1015576859
• NCBI GeneID: 29883
• NCBI Accession #: NP_001309023.1
• NCBI GenBank Nucleotide #: NM_001322094.1
• Molecular Weight: 28,228 Da
• NCBI Official Full Name: CCR4-NOT transcription complex subunit 7 isoform 4
• NCBI Official Synonym Full Names: CCR4-NOT transcription complex subunit 7
• NCBI Official Symbol: CNOT7
• NCBI Official Synonym Symbols: CAF1; CAF-1; Caf1a; hCAF-1
• NCBI Protein Information: CCR4-NOT transcription complex subunit 7
• UniProt Protein Name: CCR4-NOT transcription complex subunit 7
• Protein Family: CCR4-NOT transcription complex
• UniProt Gene Name: CNOT7
• UniProt Synonym Gene Names: CAF1; CAF-1
• UniProt Entry Name: CNOT7_HUMAN

NCBI Description

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

Uniprot Description

CNOT7: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression. Belongs to the CAF1 family.

Protein type: Transcription, coactivator/corepressor; EC 3.1.13.4

Chromosomal Location of Human Ortholog: 8p22-p21.3

Cellular Component: CCR4-NOT complex; cytosol; membrane; nucleoplasm; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding; RNA binding; signal transducer activity; transcription factor activity

Biological Process: carbohydrate metabolic process; cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; miRNA-mediated gene silencing; negative regulation of cell proliferation; poly(A) tail shortening; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; RNA-mediated gene silencing; signal transduction; transcription, DNA-dependent