Rabbit anti-Human, Mouse TRAM1 Polyclonal Antibody | anti-TRAM1 antibody

Anti-tram1 Antibody

Cat. Num. AAA7607743

• Gene Names: TRAM1; TRAM; PNAS8; TRAMP
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Synonyms: TRAM1; Polyclonal Antibody; Anti-tram1 Antibody; PNAS 8; PRO1292; TRAM; TRAMP; anti-TRAM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Sequence Length: 374

• Applicable Applications for anti-TRAM1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:2000; IHC: 1:50-1:200
• Immunogen: Translocating chain-associated membrane Protein 1
• Preparation and Storage: Store at -20 degree C for 24 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart tissue slide using MBS7607743 (tram1 antibody) at dilution of 1:200)

Western Blot (WB)

(Hela cells were subjected to SDS PAGE followed by western blot with MBS7607743 (tram1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 18202507
• NCBI GeneID: 23471
• UniProt Accession #: Q15629
• Molecular Weight: Observed MW: 43kDa
• NCBI Official Full Name: Translocating chain-associated membrane protein 1
• NCBI Official Synonym Full Names: translocation associated membrane protein 1
• NCBI Official Symbol: TRAM1
• NCBI Official Synonym Symbols: TRAM; PNAS8; TRAMP
• NCBI Protein Information: translocating chain-associated membrane protein 1
• UniProt Protein Name: Translocating chain-associated membrane protein 1
• Protein Family: Translocating chain-associated membrane protein
• UniProt Gene Name: TRAM1
• UniProt Synonym Gene Names: TRAM
• UniProt Entry Name: TRAM1_HUMAN

NCBI Description

This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

Uniprot Description

TRAM1: Stimulatory or required for the translocation of secretory proteins across the ER membrane. Belongs to the TRAM family.

Protein type: Membrane protein, multi-pass; Receptor, misc.; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q13.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; receptor activity

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; viral reproduction; gene expression; cotranslational protein targeting to membrane